Mechanoluminescence (ML) is a phenomenon in which photon emission is produced directly under mechanical stimulation. Owing to its high spatial selectivity, rapid response, and multimodal emission capabilities, ML exhibits great potential for applications in structural health monitoring, intelligent sensing, and optical anti-counterfeiting. However, due to the complexity of ML modes, categories, and underlying kinetic processes, the field still faces several challenges, including the lack of a well-established mechanism, the limited availability of high-performance ML materials, and the absence of standardized testing standards. Existing studies have demonstrated that crystal field strength, band structure, and lattice configuration play crucial roles in governing the ML properties. High-pressure, with its unique ability to adjust these physical quantities, undoubtedly provides new pathways for advancing ML research. Recent breakthroughs in rapid loading techniques have further enabled the exploration of ML behaviors under high-pressure conditions. In the GPa pressure range, modulations of interatomic distances, electronic orbitals, and crystal structures can not only effectively control emission intensity and color, but also capture ML kinetic processes in microsecond-to-second timescales, thereby supplying essential experimental data for revealing the microscopic mechanisms of ML. In this review, we first provide a brief overview of the historical development, classification, and mechanistic understanding of ML, as well as commonly used ML characterization methods under ambient and high-pressure conditions. Then, we summarize the recent progress of high-pressure techniques in optimizing ML performance and elucidating ML mechanisms, with a focus on enhancing emission intensity, adjusting spectral characteristics, and revealing dynamic processes. Finally, the future directions and challenges for high-pressure ML research are discussed.