Adopting the electroweak standard model, We analyzd the framework forms of photon γ and neutral gauge boson Z0 mixing-loop chain propagators and the relevant renormalization. Based on this, We obtained the analytic results of renormalized γ and Z0 mixing-loop chain propagators composed of different physical loops that participate in electroweak interactions. In addition, We applied our result to an important type of lepton interaction in high energy physics: e+e-→μ+μ-, then obtained the analytic result of cross section via renormalized γ and Z0 mixing-loop chain propagators. Furthermore, we compared the result with a series of experimental results, and found that the result of this paper is in good agreement with the experimental results. This study would offer certain academic reference to the theoretical study and application of common complex propagators.