In the mean-field theory and two-mode approximation, we study the self-trapping of superfluid Fermi gases in the BEC regime and in unitarity by observing the evolution of the population imbalance with time and the variation of the average of population imbalance with several non-linear interaction parameters. The high-frequency modulations of both the symmetric double-well potential and the potential well are studied. The boundary conditions of the self-trapping and non-self-trapping are given. We find that high-frequency modulation in a certain range of modulation can make the self-trapping phenomenon easier to achieve. Finally, we study the influence of the initial value on self-trapping, and find that the increase of the absolute of the initial value can make the self-trapping more conducive to the realization.