Recently, autonomous vehicles and the relevant studies have attracted much attention. Adaptive cruise control (ACC), which is a kind of cruise control system for vehicles, automatically adjusts the vehicle speed to maintain a safe distance from vehicles ahead. Since the vehicle with ACC (called ACC vehicles) is semi-autonomous, the performance of ACC vehicle must be quite different from that of manual vehicle. The characteristics of traffic flow with ACC vehicles should be carefully investigated, especially when the traffic system is a bit complicated, such as on-ramp system. The primary objective of this paper is to propose a traffic flow model to simulate the traffic flow with considering the influence of ACC vehicles and on-ramps. Based on the model proposed by Yuan in 2009 [Yuan Y M 2009 Ph. D. Dissertation (Hefei: University of Science and Technology of China)], a hybrid traffic flow model with considering the influence of ACC vehicles and on-ramps is developed. Considering the differences between ACC and manual vehicles, a car-following sub-model based on constant time headway principle is developed for ACC vehicles, while an MCD cellular automata sub-model is proposed for manual vehicles. Besides, a new parameter, , is introduced to show different psychologies of drivers when changing lane from on-ramp to main road. The lane-changing model for vehicles on-ramp is developed as well. At the end, numerical simulation is demonstrated to study the influence of ACC vehicles on traffic flow at on-ramp, and to reveal the influence of parameters on the proposed hybrid model (i.e., the length of merge area, the desired time headway of ACC vehicle and ) on model performance. The results of this paper are as follows. 1) When the ACC vehicles exist in a traffic system, the performance of traffic flow in a on-ramp area is improved: the influence of merged vehicles on main road is reduced, and the average speed and volume are increased. 2) The increase of ACC vehicles can help to alleviate traffic congestion in both congestion duration and scope aspects. 3) The newly proposed hybrid model is sensitive to the length of merge area lw, the desired time headway of ACC vehicle Hd and lane-changing psychology parameter : the decrease of Hd and the increase of can both improve the average speed and volume of traffic flow. In addition, when the volume of on-ramp is small, the speed and volume of main road can be improved by enlarging lw. When the volume of on-ramp is large, a small lw will be better for traffic flow.