This paper explores the properties of over-the-horizon propagation of infrasonic wave in the inhomogeneous atmosphere using the nonlinear progressive equation (NPE). It has been calculated for propagation and path transmission loss of infrasonic wave all the year round in Wuhan. Results show that it is obviously influenced due to infrasonic wave propagation with properties of the inhomogeneous atmosphere and winds in the inhomogeneous atmosphere. Refraction in stratosphere is related to the speed of winds and propagation direction of infrasonic wave. The minimum propagation loss is achieved when the main frequency of gauss infrasonic wave source is 0.1Hz.